3DI - SUCCESSFUL TECHNOLOGY
The objective of this study was to examine the influence of a trabecular inspired porosity manufactured by laser sintering on cell response and bone ingrowth. The effect of a 3D trabecular porosity was also observed in vivo, where porous implants were able to support vertical bone growth even without the addition of exogenous factors. Laser sintering was used to produce constructs for in vitro and implants for in vivo studies. Ti–6Al–4V implants fabricated by additive manufacturing to have porosity based on trabecular bone and post-build processing to have micro/nano surface roughness can support vertical bone growth in vivo, and suggests that these implants may be used clinically to increase osseointegration in challenging patient cases.
Additively manufactured 3D porous Ti-6Al- 4V constructs mimic trabecular bone structure and regulate osteoblast proliferation, differentiation and local factor production in a porosity and surface roughness dependent manner
Biofabrication 6 (2014)
Alice Cheng, Aiza Humayun, David J Cohen, Barbara D Boyan and Zvi Schwartz
Novel hydrophilic nanostructured microtexture on direct metal laser sintered Ti–6Al–4V surfaces enhances osteoblast response in vitro and osseointegration in a rabbit model
2016 Wiley Periodicals Inc.
Sharon L. Hyzy, Alice Cheng, David J. Cohen, Gustavo Yatzkaier, Alexander J. Whitehead, Ryan M. Clohessy, Rolando A. Gittens, Barbara D. Boyan, Zvi Schwartz
Laser Sintered Porous Ti–6Al–4V Implants Stimulate Vertical Bone Growth
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA
Alice Cheng, David J. Cohen, Adrian Kahn, Ryan M. Clohessy, Kaan Sahingur, Joseph B. Newton, Sharon L. Hyzy, Barbara D. Boyan, Zvi Schwartz